Partial knee replacements are superior economically to total knee replacements in older adults and, with a few small improvements, can be an attractive option for younger patients as well, new research from Weill Cornell Medical College and Hospital for Special Surgery investigators suggests.

Knee replacement surgeries are expected to surpass one million annually by 2020, with half of these surgeries being performed on patients younger than 65. Historically, physicians have recommended total knee replacements for all adult patients, including those who have end-stage osteoarthritis in part of the knee joint. But in their study, published March 4 in the Journal of Bone and Joint Surgery, the Weill Cornell investigators found that partial knee – also known as unicompartmental – replacements provide greater economic value to patients over the age of 65 compared with total knee replacement, as they are less likely to face surgical complications and require less physical therapy than those who undergo total knee replacement surgery.

The investigators also suggest that, if partial knee replacement devices could improve function more than total knee replacement, this procedure would be an attractive and cost-effective option for younger patients between the ages of 45 and 55, who may feel that the immediate higher quality of life benefits outweigh the risk of needing surgical revisions. Revision surgery is needed when the initial replacement fails because of infection or loosening.

Ghomrawi

“With a unicompartmental knee replacement, you’re more likely to return to work earlier and have better function compared to total knee replacement, which requires more rehabilitation and has more complications,” said lead author Dr. Hassan Ghomrawi, assistant professor in the Department of Healthcare Policy and Research at Weill Cornell and a research scientist at Hospital for Special Surgery.

While partial knee replacements traditionally have been controversial due to the higher risk of needing a revision surgery, physicians and researchers have found that this procedure offers substantial benefits. It is minimally invasive and results in less blood loss and trauma than total knee replacements. It is associated with less medical and surgical complications, such as joint infections and blood clots in the legs and lungs. And patients’ reconstructed knees tend to have a better range of motion following a shorter stint in physical therapy.

But what was less clear was whether these upfront benefits and risk of later revision surgery outweighed the long-term benefits of total knee replacement surgery for patients aged 45 to 85.

“This is one of the situations where we do a cost-effectiveness analysis to try to see which one is better over the lifetime of the patient,” Ghomrawi said.

The investigators analyzed data from the Swedish Knee Arthoplasty Register, which has the longest publicly available follow-up data on total and partial knee replacements in Sweden, as well as hospital administrative data and registry data. The researchers found that cost of care for patients undergoing partial knee replacement surgery could be substantially less than those of having total knee replacements over the course of the patients’ lifetimes. Costs associated with partial knee replacement surgery ranged from $35,000 for an 85-year-old patient to $46,600 for a 45-year-old patient, while the costs for a total knee replacement ranged from $42,000 to $47,600, respectively.

Researchers estimate that 10 to 21percent of total knee replacement patients qualify for partial knee replacement. As a result, the U.S. health care system – including patients, providers and insurers – would save $56 million if just 10 percent of older patients undergo the procedure in 2015. If 21 percent of these patients underwent the procedure, the health care system could bank more than $330 million. These savings could skyrocket in just five years to $84 million and $544 million, respectively. And they could nearly double if these surgeries become the preferred procedure for younger patients, ranging from $90 million to $582 million in 2015 and $167 million to more than $1 billion in 2020, respectively.

“This is an environment that’s increasingly cost sensitive, and we’re always looking to minimize cost of our health care system,” Ghomrawi said. “Here’s a procedure that’s going to be utilized a lot in the future, so we’re evaluating an alternative to what’s conventionally done for these patients that could save us some money and, hopefully, produce similar or better results.”

Beatrice Vantapool is a writer for Weill Cornell Medical College.