Mice without immune cells show no SARS-CoV-2 symptoms

The inflammatory response from adaptive immune cells – such as B and T lymphocytes – clears the body of the SARS-CoV-2 virus, but at the same time, it also causes the characteristic symptoms of COVID-19, a new study finds.

Contagious omicron strain replicates early in infection

New research used engineered mice to compare SARS-COV-2 omicron subvariants, and found one of them, BA.5, was more virulent likely due to its ability to rapidly replicate early during infection.

Severe COVID-19 can alter long-term immune response

Severe COVID-19 infection triggers changes that affect gene expression in immune system stem cells, causing alterations in the body’s immune response, according to a new study by Weill Cornell Medicine and Jackson Laboratory investigators.

COVID boosters show value for those pregnant or trying to conceive

Pregnant women who had a previous COVID-19 infection and received full vaccination and a booster have the strongest immune protection from the disease – and pass that protection along to their unborn babies, according to a new study.

Pandemic resulted in ‘load imbalance’ among hospitals

During the COVID-19 pandemic, many U.S. hospitals had overcapacity intensive care units while other area hospitals had open ICU beds available, a phenomenon known as “load imbalance.”

Long COVID risk and symptoms vary across populations

A new study led by Weill Cornell Medicine and NewYork-Presbyterian investigators has found that the risk of long COVID and its symptoms present very differently across diverse populations and suggests that further investigation is needed to accurately define the disease and improve diagnosis and treatment.

Hospital-at-home programs lack standards, accountability

More research and oversight are needed before making permanent a pandemic policy that allows hospitals to treat acutely ill patients in their homes, according to new Cornell research.

Vaccine campaign research highlights the power of individual self-interest

People who refused to get vaccinated against COVID-19 had low levels of social trust, weak attachments to the rule of law, and were less willing to honor collective commitments to the greater good, according to Cornell research published today.

Trial shows strong COVID protection in antibody combination

A treatment combining two antibodies against the coronavirus SARS-CoV-2 strongly protected high-risk people with early COVID-19 symptoms from hospitalization and death in an international Phase 2/3 clinical trial.